NO contribution to lipopolysaccharide-induced hepatic damage in galactosamine-sensitized mice.
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چکیده
منابع مشابه
Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice.
Fulminant hepatic failure (FHF) remains an extremely poor prognosis and high mortality; better treatments are urgently needed. Tetrandrine (TET), a traditional anti-inflammatory drug, has been reported to exhibit hepatoprotective activities in several liver injury models. We now investigated the effects and underlying mechanisms of TET on lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-in...
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The role of nitric oxide (NO) in lipopolysaccharide (LPS)-induced hepatic injury was studied in D-galactosamine (D-GalN)-sensitized mice. The inducible isoform of NO synthase (iNOS) was immunohistochemically detected on hepatocytes around blood vessels in livers of mice injected with D-GalN and LPS not on hepatocytes in mice injected with D-GalN or LPS alone, although mRNA for iNOS was found in...
متن کاملProtective effect of genistein on lipopolysaccharide/D-galactosamine- induced hepatic failure in mice.
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate aminotransferases activities and the attenuation of histopath...
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Palmatine is an isoquinoline alkaloid from Coptis chinensis, an herbal medicine used to treat various inflammatory diseases such as gastritis, edema and dermatitis. The present study examined the cytoprotective properties of palmatine on d(+)-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were intraperitoneally given GalN (700 mg/kg)/LPS (10 microg/kg). Pa...
متن کاملMetabonomics analysis of liver tissues in d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Background: Compared with biofluids, target tissues and organs may directly reflect pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS) induced mouse model was constructed to investigate metabonomics of liver tissue and characterize direct changes of substance metabolism in acute liver failure (ALF). Methods: After pretreatment of li...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1999
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.24.69